| Discussion: |
Although rare, thymoma is the most common tumor of the anterior superior mediastinum.
Of patients with thymoma, 5% develop pure red cell aplasia; 10-50% of patients with red blood cell aplasia have thymoma. Thrombocytopenia, granulocytopenia, and autoantibody formation sometimes are observed. In two thirds of individuals with red cell aplasia, morphologically, the thymoma is the spindle cell variety. Approximately 30% of patients with the disorder resume normal hematopoiesis after thymectomy (Frank, 1995; Ammann, 1997; Casadevall, 1996).